Perceptions of Methotrexate Intolerance and Its Impact on Daily Life in School-Age Children with Juvenile Idiopathic Arthritis.
Identifieur interne : 000333 ( Main/Exploration ); précédent : 000332; suivant : 000334Perceptions of Methotrexate Intolerance and Its Impact on Daily Life in School-Age Children with Juvenile Idiopathic Arthritis.
Auteurs : Sarah Khan [Canada] ; Jacqueline Mancini [Canada] ; Charlene Hopper [Canada] ; Janet E. Rennick [Canada]Source :
- Journal of pediatric nursing [ 1532-8449 ]
Descripteurs français
- KwdFr :
- Adaptation psychologique (MeSH), Antirhumatismaux (effets indésirables), Antirhumatismaux (usage thérapeutique), Anxiété (induit chimiquement), Arthrite juvénile (psychologie), Arthrite juvénile (traitement médicamenteux), Comportement de l'enfant (psychologie), Enfant (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Méthotrexate (effets indésirables), Méthotrexate (usage thérapeutique), Qualité de vie (psychologie), Résultat thérapeutique (MeSH).
- MESH :
- effets indésirables : Antirhumatismaux, Méthotrexate.
- induit chimiquement : Anxiété.
- psychologie : Arthrite juvénile, Comportement de l'enfant, Qualité de vie.
- traitement médicamenteux : Arthrite juvénile.
- usage thérapeutique : Antirhumatismaux, Méthotrexate.
- Adaptation psychologique, Enfant, Femelle, Humains, Mâle, Résultat thérapeutique.
English descriptors
- KwdEn :
- Adaptation, Psychological (MeSH), Antirheumatic Agents (adverse effects), Antirheumatic Agents (therapeutic use), Anxiety (chemically induced), Arthritis, Juvenile (drug therapy), Arthritis, Juvenile (psychology), Child (MeSH), Child Behavior (psychology), Female (MeSH), Humans (MeSH), Male (MeSH), Methotrexate (adverse effects), Methotrexate (therapeutic use), Quality of Life (psychology), Treatment Outcome (MeSH).
- MESH :
- chemical , adverse effects : Antirheumatic Agents, Methotrexate.
- chemical , therapeutic use : Antirheumatic Agents, Methotrexate.
- chemically induced : Anxiety.
- drug therapy : Arthritis, Juvenile.
- psychology : Arthritis, Juvenile, Child Behavior, Quality of Life.
- Adaptation, Psychological, Child, Female, Humans, Male, Treatment Outcome.
Abstract
PURPOSE
Methotrexate (MTX) is a disease modifying anti-rheumatic drug commonly used to treat children with Juvenile Idiopathic Arthritis (JIA). Unfortunately, half of children taking MTX will experience MTX intolerance, which includes distressing gastrointestinal and behavioural symptoms associated with weekly MTX treatment. This qualitative study aimed to explore the perceptions of school-age children with JIA experiencing MTX intolerance, how they managed MTX intolerance, and how it impacted their daily life.
DESIGN AND METHODS
An interpretive descriptive design was used. Twelve children participated in one individual 30-minute semi-structured interview using a storyboard technique to elicit their perceptions through storytelling. Interview transcripts and observational data collected during the interviews were analyzed using inductive content analysis.
RESULTS
Children described MTX intolerance as extremely challenging. Three themes emerged from the data: (1) "No kid likes taking MTX". This theme was comprised of two subthemes related to: (a) associative MTX intolerance; namely, "Talking about it sometimes makes me feel sick"; and (b) anticipatory MTX intolerance, "Before [I take it], I have a little stomach ache". Other themes included: (2) The importance of strategies and routines; and (3) Working hard to live with MTX intolerance.
CONCLUSIONS
This study sheds new light on MTX intolerance as perceived by school-aged children with JIA. Results highlight the importance of providing families and healthcare professionals with the necessary information for early recognition of MTX intolerance and optimizing care through the development of early intervention strategies.
PRACTICE IMPLICATIONS
Study findings highlight the importance of prioritizing early identification and prevention of MTX intolerance.
DOI: 10.1016/j.pedn.2019.06.004
PubMed: 31254860
Affiliations:
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Electronic address: sarah.khan@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Mancini, Jacqueline" sort="Mancini, Jacqueline" uniqKey="Mancini J" first="Jacqueline" last="Mancini">Jacqueline Mancini</name><affiliation wicri:level="4"><nlm:affiliation>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address: jacqueline.mancini@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Hopper, Charlene" sort="Hopper, Charlene" uniqKey="Hopper C" first="Charlene" last="Hopper">Charlene Hopper</name><affiliation wicri:level="1"><nlm:affiliation>The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. 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Electronic address: janet.rennick@muhc.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">Journal of pediatric nursing</title><idno type="eISSN">1532-8449</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Psychological (MeSH)</term><term>Antirheumatic Agents (adverse effects)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Anxiety (chemically induced)</term><term>Arthritis, Juvenile (drug therapy)</term><term>Arthritis, Juvenile (psychology)</term><term>Child (MeSH)</term><term>Child Behavior (psychology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Methotrexate (adverse effects)</term><term>Methotrexate (therapeutic use)</term><term>Quality of Life (psychology)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation psychologique (MeSH)</term><term>Antirhumatismaux (effets indésirables)</term><term>Antirhumatismaux (usage thérapeutique)</term><term>Anxiété (induit chimiquement)</term><term>Arthrite juvénile (psychologie)</term><term>Arthrite juvénile (traitement médicamenteux)</term><term>Comportement de l'enfant (psychologie)</term><term>Enfant (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Méthotrexate (effets indésirables)</term><term>Méthotrexate (usage thérapeutique)</term><term>Qualité de vie (psychologie)</term><term>Résultat thérapeutique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antirheumatic Agents</term><term>Methotrexate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term><term>Methotrexate</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Anxiety</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Juvenile</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antirhumatismaux</term><term>Méthotrexate</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Anxiété</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Arthrite juvénile</term><term>Comportement de l'enfant</term><term>Qualité de vie</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Arthritis, Juvenile</term><term>Child Behavior</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Arthrite juvénile</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirhumatismaux</term><term>Méthotrexate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation psychologique</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>Methotrexate (MTX) is a disease modifying anti-rheumatic drug commonly used to treat children with Juvenile Idiopathic Arthritis (JIA). Unfortunately, half of children taking MTX will experience MTX intolerance, which includes distressing gastrointestinal and behavioural symptoms associated with weekly MTX treatment. This qualitative study aimed to explore the perceptions of school-age children with JIA experiencing MTX intolerance, how they managed MTX intolerance, and how it impacted their daily life.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN AND METHODS</b></p><p>An interpretive descriptive design was used. Twelve children participated in one individual 30-minute semi-structured interview using a storyboard technique to elicit their perceptions through storytelling. Interview transcripts and observational data collected during the interviews were analyzed using inductive content analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Children described MTX intolerance as extremely challenging. Three themes emerged from the data: (1) "No kid likes taking MTX". This theme was comprised of two subthemes related to: (a) associative MTX intolerance; namely, "Talking about it sometimes makes me feel sick"; and (b) anticipatory MTX intolerance, "Before [I take it], I have a little stomach ache". Other themes included: (2) The importance of strategies and routines; and (3) Working hard to live with MTX intolerance.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>This study sheds new light on MTX intolerance as perceived by school-aged children with JIA. Results highlight the importance of providing families and healthcare professionals with the necessary information for early recognition of MTX intolerance and optimizing care through the development of early intervention strategies.</p></div><div type="abstract" xml:lang="en"><p><b>PRACTICE IMPLICATIONS</b></p><p>Study findings highlight the importance of prioritizing early identification and prevention of MTX intolerance.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31254860</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-8449</ISSN><JournalIssue CitedMedium="Internet"><Volume>48</Volume><PubDate><MedlineDate>2019 Sep - Oct</MedlineDate></PubDate></JournalIssue><Title>Journal of pediatric nursing</Title><ISOAbbreviation>J Pediatr Nurs</ISOAbbreviation></Journal><ArticleTitle>Perceptions of Methotrexate Intolerance and Its Impact on Daily Life in School-Age Children with Juvenile Idiopathic Arthritis.</ArticleTitle><Pagination><MedlinePgn>49-54</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0882-5963(18)30533-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.pedn.2019.06.004</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Methotrexate (MTX) is a disease modifying anti-rheumatic drug commonly used to treat children with Juvenile Idiopathic Arthritis (JIA). Unfortunately, half of children taking MTX will experience MTX intolerance, which includes distressing gastrointestinal and behavioural symptoms associated with weekly MTX treatment. This qualitative study aimed to explore the perceptions of school-age children with JIA experiencing MTX intolerance, how they managed MTX intolerance, and how it impacted their daily life.</AbstractText><AbstractText Label="DESIGN AND METHODS" NlmCategory="METHODS">An interpretive descriptive design was used. Twelve children participated in one individual 30-minute semi-structured interview using a storyboard technique to elicit their perceptions through storytelling. Interview transcripts and observational data collected during the interviews were analyzed using inductive content analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Children described MTX intolerance as extremely challenging. Three themes emerged from the data: (1) "No kid likes taking MTX". This theme was comprised of two subthemes related to: (a) associative MTX intolerance; namely, "Talking about it sometimes makes me feel sick"; and (b) anticipatory MTX intolerance, "Before [I take it], I have a little stomach ache". Other themes included: (2) The importance of strategies and routines; and (3) Working hard to live with MTX intolerance.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study sheds new light on MTX intolerance as perceived by school-aged children with JIA. Results highlight the importance of providing families and healthcare professionals with the necessary information for early recognition of MTX intolerance and optimizing care through the development of early intervention strategies.</AbstractText><AbstractText Label="PRACTICE IMPLICATIONS" NlmCategory="CONCLUSIONS">Study findings highlight the importance of prioritizing early identification and prevention of MTX intolerance.</AbstractText><CopyrightInformation>Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: sarah.khan@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mancini</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address: jacqueline.mancini@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>Charlene</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: charlene.hopper@muhc.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rennick</LastName><ForeName>Janet E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Ingram School of Nursing, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; Centre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: janet.rennick@muhc.mcgill.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>06</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Pediatr Nurs</MedlineTA><NlmUniqueID>8607529</NlmUniqueID><ISSNLinking>0882-5963</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>YL5FZ2Y5U1</RegistryNumber><NameOfSubstance UI="D008727">Methotrexate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>N</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000223" MajorTopicYN="N">Adaptation, Psychological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001171" MajorTopicYN="N">Arthritis, Juvenile</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002652" MajorTopicYN="N">Child Behavior</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008727" MajorTopicYN="N">Methotrexate</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anticipatory nausea</Keyword><Keyword MajorTopicYN="N">Associative nausea</Keyword><Keyword MajorTopicYN="N">Child self-report</Keyword><Keyword MajorTopicYN="N">Juvenile Idiopathic Arthritis</Keyword><Keyword MajorTopicYN="N">Methotrexate intolerance</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>06</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31254860</ArticleId><ArticleId IdType="pii">S0882-5963(18)30533-5</ArticleId><ArticleId IdType="doi">10.1016/j.pedn.2019.06.004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Khan, Sarah" sort="Khan, Sarah" uniqKey="Khan S" first="Sarah" last="Khan">Sarah Khan</name></region><name sortKey="Hopper, Charlene" sort="Hopper, Charlene" uniqKey="Hopper C" first="Charlene" last="Hopper">Charlene Hopper</name><name sortKey="Mancini, Jacqueline" sort="Mancini, Jacqueline" uniqKey="Mancini J" first="Jacqueline" last="Mancini">Jacqueline Mancini</name><name sortKey="Rennick, Janet E" sort="Rennick, Janet E" uniqKey="Rennick J" first="Janet E" last="Rennick">Janet E. 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